Immunohistochemical Assessment of GDNF and Chromogranin A Expression in Erosive and Granulomatous Lesions in Glandular Region of Equine Stomach

The equine stomach consists of two separate non-glandular and glandular sections. Despite the incidence most lesions in region, both parts are prone to lesions. In this study, 41 hybrid-native horses, including 24 stallions 17 mares, were examined over five years. total, 27 horses (65.85%) that sampled had lesions, erosion, granuloma, or on region stomach. Occurrence gastric erosive granulomatous no significant relationship with age gender sampling season (P>0.05). Moreover, parasites Gastrophilus Habronema mainly primary cause respectively. Periodic Acid Schiff (PAS) stained tissue sections, inflammation severity was higher statistically significant, compared (P<0.05). Immunohistochemistry revealed negative expression glial cell line-derived neurotrophic factor while its relatively positive normal stomachs. Interestingly, based counting cells evaluation intensity, Chromogranin A neuroendocrine a increase depth results indicated does not affect pathogenesis confirming role increment lesion progress. Furthermore, increased Ki67 p53 proteins other groups, may be associated proliferation control process measures regarding formation healing lesion.